Assoc Prof. Damjan Osredkar, MD, PhD

Contact Info

E-mail: damjan.osredkar * kclj.si
Current Address: Department of Pediatric Neurology
University Children’s Hospital Ljubljana
University Medical Centre Ljubljana
Bohoričeva 20
1525 Ljubljana
Slovenia
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Research Interests

Neuromuscular diseases, Spinal muscular atrophy, Duchenne muscular dystrophy, Novel treatment options, Neonatal and child neurology, Hypoxia, Ischemia, Hypoxic-ischemic brain and heart injury, Neuroprotective treatment, Hypothermia treatment, Brain energy metabolism, Stroke, Brain-Machine interface, Neuroimaging, Conventional and amplitude-integrated electroencephalography, Neural enhancement

Positions Held

2015 – Department for Pediatric Neurology
University Children’s Hospital
University Medical Centre Ljubljana / Slovenia
Head of the Pediatric Neurology Dpt.
2020 – Medical Faculty
University of Ljubljana / Slovenia
Associate Professor of Pediatrics
2007 – Department for Pediatric Neurology
University Children’s Hospital
University Medical Centre Ljubljana / Slovenia
Physician
2012 –
2012 – 2014
University of Oslo / Norway Guest Researcher
Postdoctoral fellow
2013 – 2014 Oslo University Hospital (Rikshospitalet) / Norway Guest Pediatric Neurologist
2007 – 2009 University of California @ San Francisco / USA Postdoctoral fellow
2003 – 2004 UMC Utrecht / The Netherlands Guest Researcher

Education

2007 University Medical Centre Ljubljana / Slovenia Specialization in Pediatrics
2006 University of Ljubljana / Slovenia PhD
2003 University of Ljubljana / Slovenia MSc
1999 University of Ljubljana / Slovenia MD

Awards / Grants

2023 Acknowledgments of the Medical Association of Slovenia Working group for managing screen time in children and adolescents
2009 UCSF Great People Award
2007 Fulbright Scholarship
2006 Best thesis award »Futurum«, Ad Futura, Funded by Slovene Government
2003 Huygens Grant Funded by Dutch Government
2001 Educational Grant International Atomic Energy Agency, IAEA
1997 Prešern’s Prize for student research Medical Faculty, University of Ljubljana

Founder / Cofounder

2017 – Hop na Grad
This fundraising event helps children treated at the University Children’s Hospital in Ljubljana, Slovenia. Three runs will be organised, with the main loop consisting of the Castle hill in Ljubljana.
2011 – Lublana
A website dedicated to promote local communities in Ljubljana/Slovenia, social connections and art
2006 Medeno srce
Cofounder of the platform for exchange of study materials and help between medical students of the Medical faculty of Ljubljana / Slovenia

Memberships

2011 – European Neonatal Brain Club
2008 – Society for Neuroscience
2006 – Sinapsa – Slovenian Neuroscience Association (founding member)

Selected Publications

Dangouloff T, Vrščaj E, Servais L, Osredkar D; SMA NBS World Study Group.
Newborn screening programs for spinal muscular atrophy worldwide: Where we stand and where to go.
Neuromuscul Disord. 2021 Apr 7:S0960-8966(21)00071-7. doi: 10.1016/j.nmd.2021.03.007. Epub ahead of print. PMID: 33985857.

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Deutsch L, Osredkar D, Plavec J, Stres B.
Spinal Muscular Atrophy after Nusinersen Therapy: Improved Physiology in Pediatric Patients with No Significant Change in Urine, Serum, and Liquor 1H-NMR Metabolomes in Comparison to an Age-Matched, Healthy Cohort.
Metabolites. 2021 Mar 30;11(4):206. doi: 10.3390/metabo11040206.

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Osredkar D, Jílková M, Butenko T, Loboda T, Golli T, Fuchsová P, Rohlenová M, Haberlova J. Children and young adults with spinal muscular atrophy treated with nusinersen. Eur J Paediatr Neurol. 2020 Dec 4;30:1-8. doi: 10.1016/j.ejpn.2020.11.004. Epub ahead of print. PMID: 33307321.
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Vrščaj E, Perković Benedik M, Oražem Mrak J, Bizjak N, Osredkar D. The perceived health of children with epilepsy, sense of control, and support for their families. Epilepsy Behav. 2020 Sep 21;112:107454. doi: 10.1016/j.yebeh.2020.107454. Epub ahead of print. PMID: 32971386.
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Martin A, Millet G, Osredkar D, Mramor M, Faes C, Gouraud E, Debevec T, Pialoux V
Effect of pre-term birth on oxidative stress responses to normoxic and hypoxic exercise
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Lancaster G, Debevec T, Millet GP, Poussel M, Willis SJ, Mramor M, Goričar K, Osredkar D, Dolžan V, Stefanovska A.
Relationship Between Cardiorespiratory Phase Coherence During Hypoxia and Genetic Polymorphism in Humans

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Debevec T, Pialoux V, Millet GP, Martin A, Mramor M, Osredkar D.
Exercise Overrides Blunted Hypoxic Ventilatory Response in Prematurely Born Men.
Front Physiol. 2019 Apr 16;10:437. doi: 10.3389/fphys.2019.00437. eCollection 2019.

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Troha Gergeli A, Neubauer D, Golli T, Butenko T, Loboda T, Maver A, Osredkar D. Prevalence and genetic subtypes of congenital myasthenic syndromes in the pediatric population of Slovenia. Eur J Paediatr Neurol. 2020 May;26:34-38. doi: 10.1016/j.ejpn.2020.02.002. Epub 2020 Feb 11. PMID: 32070632.
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Neubauer D, Perković Benedik M, Osredkar D.
Cannabidiol for treatment of refractory childhood epilepsies: Experience from a single tertiary epilepsy center in Slovenia.
Epilepsy Behav. 2018 Mar 8.

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Bizjak N, Osredkar D, Perković Benedik M, Šega Jazbec S.
Epidemiological and clinical characteristics of multiple sclerosis in paediatric population in Slovenia: A descriptive nation-wide study.Mult Scler Relat Disord. 2017 Nov;18:56-59.

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Bizjak N, Osredkar D, Meglič NP, Benedik MP.
Incidence of tonic spasms as the initial presentation of pediatric multiple sclerosis in Slovenia.
Mult Scler Relat Disord. 2017 Jul;15:47-48.

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Skranes JH, Løhaugen G, Schumacher EM, Osredkar D, Server A, Cowan FM, Stiris T, Fugelseth D, Thoresen M.
Amplitude-Integrated Electroencephalography Improves the Identification of Infants with Encephalopathy for Therapeutic Hypothermia and Predicts Neurodevelopmental Outcomes at 2 Years of Age.
J Pediatr. 2017 May 23.

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Falck M, Osredkar D, Maes E, Flatebø T, Wood TR, Sabir H, Thoresen M.
Hypothermic Neuronal Rescue from Infection-Sensitised Hypoxic-Ischaemic Brain Injury Is Pathogen Dependent.
Dev Neurosci. 2017 Apr 14. doi: 10.1159/000455838.

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Sabir H, Osredkar D, Maes E, Wood T, Thoresen M.
Xenon Combined with Therapeutic Hypothermia Is Not Neuroprotective after Severe Hypoxia-Ischemia in Neonatal Rats.
PLoS One. 2016 Jun 2;11(6):e0156759.

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Wood T, Smit E, Maes E, Osredkar D, Falck M, Elstad M, Thoresen M.
Monitoring of cerebral blood flow during hypoxia-ischemia and resuscitation in the neonatal rat using laser speckle imaging
Physiol Rep, 4 (7), 2016, e12749, doi: 10.14814/phy2.12749

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Wood T, Osredkar D, Puchades M, Maes E, Falck M, Flatebø T, Walløe L, Sabir H, Thoresen M.
Treatment temperature and insult severity influence the neuroprotective effects of therapeutic hypothermia.
Sci Rep. 2016 Mar 21;6:23430. doi: 10.1038/srep23430.

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Osredkar D, Sabir H, Falck M, Wood T, Maes E, Flatebø T, Puchades M, Thoresen M.
Hypothermia Does Not Reverse Cellular Responses Caused by Lipopolysaccharide in Neonatal Hypoxic-Ischaemic Brain Injury.
Dev Neurosci. 2015;37(4-5):390-7. doi: 10.1159/000430860. Epub 2015 Jun 12.

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Neubauer D, Soltirovska-Salamon A, Osredkar D, Paro-Panjan D.
Management of refractory neonatal seizures.
Research and Reports in Neonatology. February 2014 Volume 2014:4. Pages 17 – 29.

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Osredkar D, Thoresen M, Maes E, Flatebø T, Elstad M, Sabir H.
Hypothermia is not Neuroprotective after Infection-Sensitized Neonatal Hypoxic-Ischemic Brain Injury. Resuscitation. 2013 Dec 18.

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Chakkarapani E, Dingley J, Aquilina K, Osredkar D, Liu X, Thoresen M.
Effects of xenon and hypothermia on cerebrovascular pressure reactivity in newborn global hypoxic-ischemic pig model.
J Cereb Blood Flow Metab. 2013 Jul 31.
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Radšel A, Andlovic A, Neubauer D, Osredkar D.
Infant botulism: First two confirmed cases in Slovenia and literature review.
Eur J Paediatr Neurol. 2013 May 23.
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Thoresen M, Osredkar D.
Brain wave recovery predicts outcome after cardiac arrest.
Resuscitation. 2012 Nov 29.
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Osredkar D, Neubauer D.
Najpogostejše epilepsije po neonatalnem obdobju.
Medicinski razgledi. 2012; 51: 39–50.
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Neubauer D, Osredkar D, Paro-Panjan D, Skofljanec A, Derganc M.
Recording conventional and amplitude-integrated EEG in neonatal intensive care unit.
Eur J Paediatr Neurol. 2011 Sep;15(5):405-16.
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Osredkar D, Sall JW, Bickler PE, Ferriero DM.
Erythropoietin promotes hippocampal neurogenesis in in-vitro models of neonatal stroke.
Neurobiol Dis. 2010 Jan 28.
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Sheldon RA, Osredkar D, Lee CL, Jiang X, Mu D, Ferriero DM.
HIF-1alpha-Deficient Mice Have Increased Brain Injury after Neonatal Hypoxia-Ischemia.
Dev Neurosci. 2009 Aug 11;31(5):452-458.
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Derganc M, Osredkar D.
Hypoxic-ischemic brain injury in the neonatal period – current concepts, noveldiagnostic approaches and neuroprotective strategies = Hipoksično-ishemična okvara možganov v neonatalnem obdobju – sodobni pogledi, nove diagnostične metode in nevroprotektivni ukrepi.
Zdrav Vestn (Tisk. izd.). 2008, letn. 77, suppl. II, str. II-51-II-8.
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van Rooij LG, Toet MC, Osredkar D, van Huffelen AC, Groenendaal F, de Vries LS.
Recovery of amplitude integrated electroencephalographic background patterns within 24 hours of perinatal asphyxia.
Arch Dis Child Fetal Neonatal Ed. 2005 May;90(3):F245-f251.
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Toet MC, Groenendaal F, Osredkar D, van Huffelen AC, de Vries LS.
Postneonatal epilepsy following amplitude-integrated EEG-detected neonatal seizures.
Pediatr Neurol. 2005 Apr;32(4):241-247.
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Osredkar D, Toet MC, van Rooij LG, van Huffelen AC, Groenendaal F, de Vries LS.
Sleep-wake cycling on amplitude-integrated electroencephalography in term newborns with hypoxic-ischemic encephalopathy.
Pediatrics. 2005 Feb;115(2):327-32.
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